KMID : 0624620220550110519
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BMB Reports 2022 Volume.55 No. 11 p.519 ~ p.527
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The role of immunomodulatory metabolites in shaping the inflammatory response of macrophages
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Park Do-Young
Lim Gyu-Min Yoon Sung-Jin Yi Hyon-Seung Choi Dong-Wook
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Abstract
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Macrophage activation has long been implicated in a myriad of human pathophysiology, particularly in the context of the dysregulated capacities of an unleashing intracellular or/and extracellular inflammatory response. A growing number of studies have functionally coupled the macrophages¡¯ inflammatory capacities with dynamic metabolic reprogramming which occurs during activation, albeit the results have been mostly interpreted through classic metabolism point of view; macrophages take advantage of the rewired metabolism as a source of energy and for biosynthetic precursors. However, a specific subset of metabolic products, namely immune-modulatory metabolites, has recently emerged as significant regulatory signals which control inflammatory responses in macrophages and the relevant extracellular milieu. In this review, we introduce recently highlighted immuno-modulatory metabolites, with the aim of understanding their physiological and pathological relevance in the macrophage inflammatory response.
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KEYWORD
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Immuno-modulatory metabolites, Inflammatory diseases, Macrophages
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